ANDOR DR-328G-C02-SIL Microscope Camera Clara

( Brand: Andor ), ( Manufacturer Part Number: DR-328G-C02-SIL ), ( Part Type: Camera )

Review ANDOR Microscope Camera Clara Model

The **Andor Clara E-328G-C02-SIL** is a high-performance, scientific-grade digital camera designed to deliver exceptional image quality and reliability for advanced microscopy applications. Engineered by Andor Technology, a leader in photonics and imaging solutions, this monochrome, back-illuminated CCD camera is optimized for demanding research environments where precision, sensitivity, and speed are critical. Its **16-bit analog-to-digital converter (ADC)** ensures superior dynamic range, capturing subtle variations in sample contrast with remarkable clarity, while the **1024 1024 pixel resolution** provides fine spatial detail essential for high-magnification imaging, such as fluorescence microscopy, confocal microscopy, and live-cell imaging. The camera s **back-illuminated (BI) sensor** enhances quantum efficiency, particularly in the visible and near-UV spectrums, making it ideal for low-light conditions where traditional front-illuminated sensors would struggle. With a **cooling capability down to -35 C**, the Clara E-328G-C02-SIL minimizes thermal noise, further improving signal-to-noise ratios in long-exposure or low-light imaging scenarios, such as fluorescence tagging or single-molecule studies.

Built with durability in mind, this camera features a robust **silicon housing** that protects against environmental factors, ensuring stability in laboratory settings where vibrations or temperature fluctuations could otherwise compromise image integrity. Its **high-speed readout** achieved through a **16 MHz clock speed** allows for rapid frame acquisition, making it suitable for dynamic processes like time-lapse imaging or high-speed confocal scanning. The Clara E-328G-C02-SIL integrates seamlessly with Andor s **Solis** software suite, offering intuitive control over exposure settings, gain adjustments, and real-time image preview, while also supporting third-party software for automated data acquisition and analysis. Whether used in cellular biology, materials science, or neuroscience, this camera s combination of **high sensitivity, low noise, and precise control** makes it an indispensable tool for researchers seeking uncompromising image quality in their microscopy workflows. Its compact yet sturdy design also ensures compatibility with a wide range of microscope models, from inverted to upright systems, while its **USB 3.0 interface** facilitates high-bandwidth data transfer for efficient workflow management.

The **Andor Clara DR-328G-C02-SIL** is a high-end scientific CMOS (sCMOS) camera designed for advanced microscopy applications, particularly fluorescence and live-cell imaging. Below is a detailed breakdown of its pros and cons, followed by a conclusion and recommendation.

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### **Pros of the Andor Clara DR-328G-C02-SIL**

1. **Exceptional Sensitivity and Low Read Noise**

The camera features Andor s **DR (Direct Readout) sCMOS technology**, which combines high quantum efficiency (QE) with low read noise (as low as 0.9 electrons RMS). This makes it ideal for detecting faint signals in low-light conditions, such as single-molecule imaging or weak fluorescence.

2. **High Dynamic Range**

With a dynamic range of **16-bit**, the camera captures both bright and dim signals within a single exposure, reducing the need for multiple exposures or HDR techniques. This is particularly useful in live-cell imaging where contrast varies significantly across the field of view.

3. **Fast Frame Rates**

The **328 328 pixel sensor** (with optional binning) allows for relatively high frame rates (up to ** 30 fps at full resolution** with minimal readout noise), making it suitable for dynamic processes like calcium imaging, fluorescence recovery after photobleaching (FRAP), or fast kinetics studies.

4. **Low Dark Current**

The camera has a **very low dark current** (typically

5. **High Quantum Efficiency (QE)**

The sensor achieves ** 90% QE at 550 nm**, one of the highest in its class, ensuring maximum photon capture efficiency for fluorescence applications.

6. **Silent Operation**

The **"Silent" mode** reduces mechanical noise from the shutter, which is beneficial for high-precision imaging where vibrations could introduce artifacts.

7. **Compatibility with Andor s Software Suite**

The camera integrates seamlessly with **Andor s Solis software**, which offers advanced features like **autofocus, drift correction, and multi-dimensional data acquisition**. It also supports ** Manager, MetaMorph, and other third-party imaging software**.

8. **Compact and Robust Design**

The camera is designed for **microscope compatibility**, with a **C-mount or S-mount adapter** (depending on the model variant) and a sturdy build for laboratory use.

9. **Low Light Lag**

Andor s sCMOS sensors are engineered to minimize **light lag** (the persistence of signal after exposure), which is crucial for time-lapse imaging where artifacts could distort results.

10. **Global Shutter Capability (Optional)**

While not a true global shutter, the camera supports **rolling shutter correction techniques** and can be paired with systems that mitigate rolling shutter artifacts.

11. **Long-Term Stability**

Andor cameras are known for their **reliability and longevity**, with many users reporting minimal degradation over years of use.

12. **Support for Advanced Filter Wheels and Illumination**

The camera works well with **Andor s filter wheels and LED illumination systems**, enabling flexible experimental setups for multi-channel imaging.

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### **Cons of the Andor Clara DR-328G-C02-SIL**

1. **High Cost**

The camera is **one of the most expensive sCMOS options** on the market, often costing **$30,000 $50,000 ** depending on configuration. This makes it a significant investment, especially for smaller labs or students.

2. **Limited Field of View**

The **328 328 pixel sensor** provides a relatively small field of view compared to larger sCMOS cameras (e.g., 2048 2048). This may require **higher magnification objectives** or **stitching techniques** for wider imaging needs.

3. **No True Global Shutter**

Like most sCMOS cameras, it uses a **rolling shutter**, which can introduce artifacts in fast-moving samples or when imaging objects with high-speed motion. While software corrections exist, they may not fully eliminate all issues.

4. **Cooling Requirement**

While the camera performs well at room temperature, **active cooling (Peltier)** is recommended for extended imaging sessions to further reduce dark current and noise. This adds to the overall cost and complexity.

5. **Software Dependency**

Full functionality relies on **Andor s proprietary software (Solis)**, which may require a learning curve. Some users prefer **open-source alternatives** like Manager but may need additional configuration.

6. **Limited Pixel Size**

The **pixel size is 6.5 m**, which may not be optimal for all applications requiring higher resolution or specific magnification setups.

7. **Maintenance and Calibration Needs**

High-end cameras require **periodic calibration and maintenance** to ensure optimal performance, which may involve additional costs and downtime.

8. **Not Ideal for Brightfield or Phase Contrast**

While capable of brightfield imaging, the camera is **primarily optimized for fluorescence**, so it may not be the best choice for non-fluorescent techniques.

9. **Cooling System Complexity**

If using a **Peltier cooler**, the system becomes more complex, requiring stable power and proper thermal management.

10. **Resale Value Depreciation**

Like most high-end lab equipment, the camera s value depreciates over time, which may be a consideration for budget-conscious buyers.

---

### **Conclusion**

The **Andor Clara DR-328G-C02-SIL** is a **premium sCMOS camera** that excels in **high-sensitivity fluorescence imaging, live-cell studies, and low-light applications**. Its **low noise, high dynamic range, and fast frame rates** make it a top choice for researchers requiring **high-resolution, high-precision imaging**. However, its **high cost, limited field of view, and dependency on proprietary software** may not make it suitable for all laboratories, particularly those with **tight budgets or non-fluorescence applications**.

- **Fluorescence microscopy (including live-cell imaging)**

- **Single-molecule and super-resolution techniques**

- **Applications requiring minimal noise and high sensitivity**

- **Researchers who can justify the investment in advanced imaging**

For users who need **larger fields of view, true global shutter, or cost-effective alternatives**, other cameras like **Hamamatsu Orca Flash4.0, Teledyne Photometrics Prime 95B, or Zyla 5.5** may be more appropriate.

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### **Recommendation**

- You are working in **fluorescence microscopy, live-cell imaging, or low-light applications** where **sensitivity and dynamic range are critical**.

- Your budget allows for a **high-end investment** in imaging technology.

- You require **Andor s software ecosystem** and compatibility with their illumination/filter systems.

- You need **minimal noise and fast frame rates** for dynamic processes.

- You need a **larger field of view** (e.g., 2048 2048 pixels).

- Your budget is constrained, and you can find a **similar-performing camera at a lower cost** (e.g., Hamamatsu or Teledyne options).

- You require **true global shutter** capabilities.

- Your primary application is **brightfield or phase contrast** rather than fluorescence.

For most **advanced fluorescence microscopy labs**, the **Andor Clara DR-328G-C02-SIL remains one of the best choices** due to its **unmatched sensitivity and reliability**, but potential buyers should carefully weigh the cost against their specific needs.

Details:

Its compatibility with microscopes ensures a seamless integration for enhanced viewing and imaging capabilities. The Andor Microscope Camera Clara model DR-328G-C02-SIL is a high-quality microscope camera designed for medical and laboratory applications. With its advanced technology and precision engineering, this camera provides clear detailed images for analysis inspection.

part #: dr328gc02 price

• $2000.00

specifications microscopepartzo:

• brand: Andor
• mpn: Dr-328g-c02-sil
• part type: Camera

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• carrier: USPS
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• class: Standard
• cost: $8.81
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• transit: 12-15 Days

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• policy: No Returns

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• options: Ship-to-home
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• started: April 15, 2026
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• city: Bel Air, Maryland

general microscopepartzo:

• Medical/Lab Equipment Attachments Accessories > Microscope Parts Accessories > Other Microscope Parts Accessories
• condition: Used

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