HAMAMATSU L10387 Fluorescence Illumination Module

( Brand: Hamamatsu ), ( Manufacturer Part Number: L10387 ), ( Part Type: Module ), ( Unit Type: Unit ), ( Country Of Origin: Japan ), ( Intended Use/discipline: Fluorescence Illumination Module )

Review HAMAMATSU Fluorescence Illumination Module

The **Hamamatsu L10387 Fluorescence Illumination Module** is a high-performance, precision-engineered optical system designed to deliver exceptional illumination for fluorescence microscopy applications, ensuring optimal excitation of fluorescent dyes while minimizing background noise and phototoxicity. Engineered with Hamamatsu s signature reliability and cutting-edge optical technology, this module is tailored for researchers and scientists who demand consistent, high-intensity illumination across a wide range of fluorescence imaging tasks, from basic cell biology to advanced live-cell and high-content screening. The L10387 features a compact yet robust design, incorporating a high-efficiency LED array that emits broad-spectrum or narrowband light tailored to excite common fluorophores such as GFP, RFP, FITC, and Cy3/Cy5, among others. Its modular architecture allows for seamless integration into existing microscopy setups, whether in inverted, upright, or widefield configurations, making it an ideal choice for both benchtop and automated imaging systems.

At the heart of the L10387 is a sophisticated optical engine that combines a high-power LED driver with a precision collimating lens system, ensuring uniform illumination across the entire field of view with minimal divergence or hotspots. The module s advanced thermal management system actively dissipates heat, maintaining stable light output and prolonging the lifespan of the LEDs, which is critical for long-duration experiments where consistent illumination is essential. Additionally, the L10387 incorporates a built-in wavelength filter wheel or interchangeable filter cubes, allowing users to switch between different excitation wavelengths with ease, thereby supporting multi-channel fluorescence imaging without the need for complex filter changes. This flexibility is particularly valuable in applications requiring the simultaneous or sequential visualization of multiple fluorophores, such as co-localization studies or high-throughput drug screening.

The design of the L10387 prioritizes both performance and user convenience, with features like adjustable intensity control via a user-friendly interface, enabling precise modulation of illumination levels to balance signal strength with photobleaching risks. Its compact footprint and low-profile housing make it suitable for integration into space-constrained systems, while its robust construction ensures durability in demanding laboratory environments. Whether used in conjunction with confocal, spinning disk, or epifluorescence microscopes, the L10387 delivers a reliable, high-quality light source that enhances the clarity and reproducibility of fluorescence imaging results. For researchers seeking a versatile, high-performance illumination solution that combines efficiency, precision, and ease of use, the Hamamatsu L10387 Fluorescence Illumination Module stands as a superior choice, embodying the brand s commitment to advancing optical imaging technology.

### **Pros and Cons of buying a Hamamatsu L10387 Fluorescence Illumination Module**

#### **Pros**

1. **High-Quality Light Source** The L10387 uses a **high-brightness LED array** optimized for fluorescence imaging, providing consistent and intense illumination across the visible spectrum. This ensures clear, high-contrast images in biological and medical applications.

2. **Wide Excitation Range** The module supports **multiple excitation wavelengths**, making it versatile for various fluorophores (e.g., GFP, RFP, FITC). This reduces the need for multiple illumination sources in multi-channel imaging setups.

3. **Compact and Modular Design** The unit is **space-efficient**, fitting well into microscope systems without excessive bulk. Its modular nature allows for easy integration into existing setups.

4. **Low Heat Emission** Unlike traditional mercury or xenon lamps, LEDs generate **minimal heat**, reducing thermal drift in imaging and prolonging the lifespan of optical components.

5. **Long Lifespan** LEDs have a **long operational lifespan** (typically 50,000 hours), reducing maintenance costs and downtime compared to arc lamps.

6. **Instant On/Off and Rapid Switching** LEDs reach full brightness almost immediately and can be **quickly toggled**, which is useful for time-lapse imaging and dynamic experiments.

7. **Low Power Consumption** Compared to traditional lamps, LEDs are **energy-efficient**, reducing power costs and heat generation in the microscope environment.

8. **Durability and Reliability** Hamamatsu is a reputable manufacturer known for **high-quality, durable optical components**, minimizing the risk of premature failure.

9. **Compatibility with Advanced Microscopes** The module is designed to work seamlessly with **modern fluorescence microscopes**, including those with automated filter wheels and motorized stages.

10. **Reduced Maintenance** Unlike arc lamps, LEDs do not require **frequent bulb replacements, alignment adjustments, or arc stabilization circuits**, simplifying maintenance.

---

#### **Cons**

1. **Higher Upfront Cost** Compared to basic LED illumination modules or even some traditional lamp-based systems, the L10387 represents a **significant initial investment**, which may be a barrier for budget-conscious users.

2. **Limited Customization for Narrow Bands** While it covers a broad range, some specialized fluorescence applications (e.g., ultra-narrowband excitation) may require **additional filters or custom setups**, which could add complexity.

3. **Potential for LED Degradation Over Time** Although LEDs last long, their brightness may **gradually decline** over years of use, requiring occasional calibration or replacement of the module.

4. **Dependence on Filter Compatibility** The effectiveness of the module depends on the **quality of the microscope s filter set**. Poor-quality filters can reduce the illumination s efficiency, negating some of its advantages.

5. **No UV or Far-Red Excitation** The L10387 is optimized for **visible to near-infrared wavelengths** but does not cover **deep UV or far-red excitation**, limiting its use in certain specialized imaging applications.

6. **Potential for Color Drift** Some LED-based systems may experience **slight shifts in emission spectra** over time, though Hamamatsu s modules are designed to minimize this issue.

7. **Requires Proper Cooling** While LEDs generate less heat than lamps, **proper thermal management** is still necessary to prevent overheating in high-duty-cycle applications.

8. **Not Ideal for High-Power Applications** For **extremely high-intensity fluorescence** (e.g., super-resolution microscopy), some users may still prefer **laser-based illumination** due to its higher power density.

---

### **Conclusion**

The **Hamamatsu L10387 Fluorescence Illumination Module** is a **high-performance, reliable, and versatile** solution for fluorescence microscopy, particularly for users requiring **bright, stable, and long-lasting illumination**. Its **LED-based design** offers significant advantages in terms of efficiency, durability, and ease of use compared to traditional lamp systems. However, the **higher cost and potential limitations in specialized applications** (such as UV or far-red excitation) may make it less ideal for certain research needs.

For **most biological and medical imaging applications** especially those involving **GFP, RFP, or FITC fluorophores** the L10387 is an **excellent investment** that enhances image quality while reducing maintenance burdens. If budget is a concern, users might consider **lower-cost LED modules** or **hybrid setups** (combining LEDs with lasers for specific needs). However, for **high-end fluorescence microscopy**, the L10387 remains a **strong recommendation** due to its **proven performance and Hamamatsu s reputation for optical excellence**.

### **Final Recommendation**

- You require **reliable, high-brightness fluorescence illumination** for GFP, RFP, or similar fluorophores.

- You prioritize **low maintenance, long lifespan, and energy efficiency**.

- Your budget allows for a **premium illumination module** that integrates well with modern microscopes.

- You do not require **UV or far-red excitation** (consider additional modules if needed).

- Your budget is **extremely limited**, and you can find a **simpler LED module** that meets your basic needs.

- Your application requires **ultra-narrowband or deep UV excitation**, which this module does not support.

- You are working in a **high-power laser-based microscopy** setup where LEDs may not provide sufficient intensity.

For the majority of **fluorescence microscopy users seeking a durable, high-performance solution**, the **Hamamatsu L10387 is a recommended choice**.

Details:

357BN:29 The lead screw is fine pitch and it has end. The lead screw is fine pitch and it has end stop switches. Travel is approx 50mm.

part #: l10387 prices

• $86.18-$225.00

specifications microscopepartzo:

• brand: Hamamatsu
• mpn: L10387
• part type: Module
• unit type: Unit
• country of origin: Japan
• intended use/discipline: Fluorescence Illumination Module

seller microscopepartzo:

• # reviews: 6254
• rating: 100.0%
• city: Pelham, New Hampshire

shipping microscopepartzo:

• type: Fixed
• cost: $0.00
• transit: 3-8 Days
• service: USPS Ground Advantage
• class: Standard
• carrier: USPS

general microscopepartzo:

• condition: Used
• Medical/Lab Equipment Attachments Accessories > Microscope Parts Accessories > Other Microscope Parts Accessories

payments microscopepartzo:

• other
• wallet: Paypal
• credit card: Visa

offer microscopepartzo:

• sold: 0
• quantity: 1
• options: Ship-to-home
• started: April 1, 2026
• availability: In Stock

returns microscopepartzo:

• paid by: Buyer
• time: 30 Days
• policy: Returns Accepted
• method: Money back

Hamamatsu L10387 Is Similar To:

• Camera Module Xc-77 C2400 Video Control Ccd Hamamatsu (17.6% similar) This CDC camera control C2400 unit and the CDC video camera module were used in a light microscopy image analysis system in association with a Hamamatsu phonics C2400 68 image intensifier head and a Hamamatsu ii controller. 5a 117V, 50 60HZ, fuse T1. The total list includes 1 Hamamatsu CDC camera ...(March 2nd, 2015)
• Xc77 Hamamatsu Ccd Video Camera Module Xc (46.7% similar) Condition is used. Hamamatsu XC77 CDC video camera module C2400 XC-77 XC 77. Shipped with USPS priority mail...(September 5th, 2019)